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Avapritinib: preclinical studies of a promising novel therapeutic option for gastrointestinal stromal tumors

   
@article{GIST27016,
	author = {Milena Urbini},
	title = {Avapritinib: preclinical studies of a promising novel therapeutic option for gastrointestinal stromal tumors},
	journal = {Gastrointestinal Stromal Tumor},
	volume = {2},
	number = {0},
	year = {2019},
	keywords = {},
	abstract = {Gastrointestinal stromal tumors (GISTs) represent the most common mesenchymal tumor of the gastrointestinal tract (80%), with an annual incidence of 10–15 cases per million people (1). GISTs have become a paradigm for the use of molecular diagnostics and targeted therapy, since its molecular classification is able to predict treatment response. Most GISTs are driven by activating mutations in KIT (70–80% of cases) or PDGFRA (10%) receptor tyrosine kinases. This discovery represents the rationale of the efficacy of target therapies efficacy using small molecule tyrosine kinase inhibitors (TKIs) for this malignancy (1,2).},
	issn = {2663-1911},	url = {https://gist.amegroups.org/article/view/27016}
}